منابع مشابه
Biologics Will Pump Up the Vasculitis Market.
Vasculitis, a group of heterogeneous disorders characterized by inflammation and necrosis of the blood vessels, has but one treatment approved by the Food and Drug Administration. However, six novel biologic candidates are in late-stage development.
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Oligomeric forms of the Parkinson’s disease-causing protein a-synuclein are suspected to mediate neurodegeneration, but the mechanisms are not understood. The present study of Shrivastava et al (2015) provides a fresh insight into this old mystery. a-Synuclein oligomers are shown by a combination of top state-of-the-art biochemical and super-resolution microscopy methods to sequester the neuron...
متن کاملTuning extension of a Difference-Frequency generation up to 100 nm using V-shaped external-cavity for the pump laser
In this research, tunability of a commercial diode laser has extended to about more than ± 11 nm using a V-shaped external-cavity fabricated around the laser. Although under normal condition it can be tuned up to about ± 4 nm just by changing its temperature and injection current. Such modified diode laser has then used in a difference-frequency generation (DFG) experimental setup as pump sourc...
متن کاملDystroglycan Versatility
cytoskeleton, thus stabilizing the muscle as it alternately Martin E. Hemler Dana-Farber Cancer Institute contracts and relaxes. In particular, the a-dystroglycan protein binds to the extracellular matrix protein Boston, Massachusetts 02115 laminin-2, while b-dystroglycan spans the membrane and links directly to dystrophin, and other cytoskeletal proteins in the dystrophin family (Figure 1A). T...
متن کاملThe chemical versatility of RNA.
The ability of RNA to both store genetic information and catalyse chemical reactions has led to the hypothesis that it predates DNA and proteins. While there is no doubt that RNA is capable of storing the genetic information of a primitive organism, only two classes of reactions-phosphoryl transfer and peptide bond formation-have been observed to be catalysed by RNA in nature. However, these na...
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ژورنال
عنوان ژورنال: Nature
سال: 2000
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35023203